ea0029p1026 | Male Reproduction | ICEECE2012
Beltrame F.
, Cerri P.
, Sasso-Cerri E.
Cimetidine, an antagonist of histamine H2-receptors used for treatment of gastric ulcers, exerts antiandrogenic effect. In testes, cimetidine causes histopathological disorders in the seminiferous tubules and impairs spermatogenesis. Additionally to testosterone, Leydig cells (LC) produce several paracrine factors, including EGVEGF (endocrine gland-derived vascular endothelial growth factor) which participates in the testicular microvasculature control. Regarding the imp...